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The functional design of the rotary enzyme ATP synthase is consistent with maximum entropy production

Dewar, Roderick; Juretic, D; Zupanovic, P


We show that the molecular motor ATP synthase has evolved in accordance with the statistical selection principle of Maximum Shannon Entropy and one of its corollaries, Maximum Entropy Production. These principles predict an optimal angular position for the ATP-binding transition close to the experimental value; an inverse relation between the optimal gearing ratio and the proton motive force (pmf); optimal operation at an inflection point in the curve of ATP synthesis rate versus pmf, enabling...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Chemical Physics Letters
DOI: 10.1016/j.cplett.2006.08.095


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