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Targeted Liposomal Delivery of TLR9 Ligands Activates Spontaneous Antitumor Immunity in an Autochthonous Cancer Model

Hamzah, Juliana; Altin, Joseph; Herringson, Thomas; Hammerling, G; O'Donoghue, Helen; Ganss, Ruth; Parish, Christopher


Accessibility of tumors for highly effective local treatment represents a major challenge for anticancer therapy. Immunostimulatory oligodeoxynucleotides (ODN) with CpG motifs are ligands of TLR9, which prime spontaneous antitumor immunity, but are less effective when applied systemically. We therefore developed a liposome-based agent for selective delivery of CpG-ODN into the tumor environment. A peptide that specifically targets angiogenic endothelial cells in a transgenic tumor model for...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Journal of Immunology
DOI: 10.4049/jimmunol.0900736


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