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Caspase 1 deficiency reduces inflammation-induced brain transcription

Mastronardi, Claudio; Whelan, Fiona; Yildiz, Ozlem A.; Hannestad, Jonas; Elashoff, Robert M.; McCann, Samuel M.; Licinio, Julio; Wong, Ma-Li


The systemic inflammatory response syndrome (SIRS) is a life-threatening medical condition characterized by a severe and generalized inflammatory state that can lead to multiple organ failure and shock. The CNS regulates many features of SIRS such as fever, cardiovascular, and neuroendocrine responses. Central and systemic manifestations of SIRS can be induced by LPS or IL-1β administration. The crucial role of IL-1β in inflammation has been further highlighted by studies of mice lacking...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.0701366104


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