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Feedback Inhibition of Pantothenate Kinase Regulates Pantothenol Uptake by the Malaria Parasite

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Lehane, Adele; Marchetti, Rosa; Spry, Christina; Van Schalkwyk, Donelly; Teng, Rongwei; Kirk, Kiaran; Saliba, Kevin

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To survive, the human malaria parasite Plasmodium falciparum must acquire pantothenate (vitamin B5) from the external medium. Pantothenol (provitamin B5) inhibits parasite growth by competing with pantothenate for pantothenate kinase, the first enzyme in

dc.contributor.authorLehane, Adele
dc.contributor.authorMarchetti, Rosa
dc.contributor.authorSpry, Christina
dc.contributor.authorVan Schalkwyk, Donelly
dc.contributor.authorTeng, Rongwei
dc.contributor.authorKirk, Kiaran
dc.contributor.authorSaliba, Kevin
dc.date.accessioned2015-12-08T22:22:11Z
dc.identifier.issn0021-9258
dc.identifier.urihttp://hdl.handle.net/1885/32459
dc.description.abstractTo survive, the human malaria parasite Plasmodium falciparum must acquire pantothenate (vitamin B5) from the external medium. Pantothenol (provitamin B5) inhibits parasite growth by competing with pantothenate for pantothenate kinase, the first enzyme in
dc.publisherAmerican Society for Biochemistry and Molecular Biology Inc
dc.sourceJournal of Biological Chemistry
dc.subjectKeywords: Alcohols; Biosynthesis; Cell culture; Diseases; Microorganisms; Vitamins; Erythrocyte; Pantothenate; Pantothenate kinase; Pantothenol; Enzyme inhibition; coenzyme A; dexpanthenol; furosemide; pantothenate kinase; article; enzyme synthesis; erythrocyte; ne
dc.titleFeedback Inhibition of Pantothenate Kinase Regulates Pantothenol Uptake by the Malaria Parasite
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume282
dc.date.issued2007
local.identifier.absfor060502 - Infectious Agents
local.identifier.absfor060107 - Enzymes
local.identifier.absfor111501 - Basic Pharmacology
local.identifier.ariespublicationu4325460xPUB92
local.type.statusPublished Version
local.contributor.affiliationLehane, Adele, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMarchetti, Rosa, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSpry, Christina, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationVan Schalkwyk, Donelly, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationTeng, Rongwei, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKirk, Kiaran, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSaliba, Kevin, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue35
local.bibliographicCitation.startpage25395
local.bibliographicCitation.lastpage25405
local.identifier.doi10.1074/jbc.M704610200
dc.date.updated2015-12-08T08:42:06Z
local.identifier.scopusID2-s2.0-34548483181
CollectionsANU Research Publications

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