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Feedback Inhibition of Pantothenate Kinase Regulates Pantothenol Uptake by the Malaria Parasite

Lehane, Adele; Marchetti, Rosa; Spry, Christina; Van Schalkwyk, Donelly; Teng, Rongwei; Kirk, Kiaran; Saliba, Kevin


To survive, the human malaria parasite Plasmodium falciparum must acquire pantothenate (vitamin B5) from the external medium. Pantothenol (provitamin B5) inhibits parasite growth by competing with pantothenate for pantothenate kinase, the first enzyme in

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M704610200


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