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Dicer-dependent microRNA pathway safeguards regulatory T cell function

Liston, Adrian; Lu, Li-Fan; O'Carroll, D C; Tarakhovsky, Alexander; Rudensky, Alexander

Description

Regulatory T (T reg) cells are indispensable for preventing autoimmunity. Incumbent to this role is the ability of T reg cells to exert their suppressor function under inflammatory conditions. We found that T reg cell-mediated tolerance is critically dependent on the Dicer-controlled microRNA (miRNA) pathway. Depletion of miRNA within the T reg cell lineage resulted in fatal autoimmunity indistinguishable from that in T reg cell-deficient mice. In disease-free mice lacking Dicer in all T cells...[Show more]

dc.contributor.authorListon, Adrian
dc.contributor.authorLu, Li-Fan
dc.contributor.authorO'Carroll, D C
dc.contributor.authorTarakhovsky, Alexander
dc.contributor.authorRudensky, Alexander
dc.date.accessioned2015-12-08T22:22:03Z
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/1885/32393
dc.description.abstractRegulatory T (T reg) cells are indispensable for preventing autoimmunity. Incumbent to this role is the ability of T reg cells to exert their suppressor function under inflammatory conditions. We found that T reg cell-mediated tolerance is critically dependent on the Dicer-controlled microRNA (miRNA) pathway. Depletion of miRNA within the T reg cell lineage resulted in fatal autoimmunity indistinguishable from that in T reg cell-deficient mice. In disease-free mice lacking Dicer in all T cells or harboring both Dicer-deficient and -sufficient T reg cells, Dicer-deficient T reg cells were suppressive, albeit to a lesser degree, whereas their homeostatic potential was diminished as compared with their Dicer-sufficient counterparts. However, in diseased mice, Dicer-deficient T reg cells completely lost suppressor capacity. Thus, miRNA preserve the T reg cell functional program under inflammatory conditions.
dc.publisherRockefeller University Press
dc.sourceJournal of Experimental Medicine
dc.subjectKeywords: dicer; microRNA; animal experiment; animal tissue; article; autoimmunity; cell function; homeostasis; inflammation; mouse; nonhuman; priority journal; regulatory T lymphocyte; Animals; Apoptosis; Autoimmunity; Cell Lineage; Cell Proliferation; DEAD-box RN
dc.titleDicer-dependent microRNA pathway safeguards regulatory T cell function
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume205
dc.date.issued2008
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationu6800332xPUB91
local.type.statusPublished Version
local.contributor.affiliationListon, Adrian, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLu, Li-Fan, University of Washington
local.contributor.affiliationO'Carroll, D C, University of Washington
local.contributor.affiliationTarakhovsky, Alexander, The Rockefeller University
local.contributor.affiliationRudensky, Alexander, University of Washington
local.description.embargo2037-12-31
local.bibliographicCitation.issue9
local.bibliographicCitation.startpage1993
local.bibliographicCitation.lastpage2004
local.identifier.doi10.1084/jem.20081062
dc.date.updated2015-12-08T08:40:43Z
local.identifier.scopusID2-s2.0-51049110261
CollectionsANU Research Publications

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