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Deletion of the Ttf1 Gene in Differentiated Neurons Disrupts Female Reproduction without Impairing Basal Ganglia Function

Mastronardi, Claudio; Smiley, Gregory; Raber, Jacob; kusakabe, T; Kawagushi, Akio; Matagne, Valerie; Dietzel, A; Heger, Sabine; Mungenast, Alison E; Cabrera, Ricardo; Kimura, Shioko; Ojeda, Sergio R


Thyroid transcription factor 1 (TTF1) [also known as Nkx2.1 (related to the NK-2 class of homeobox genes) and T/ebp (thyroid-specific enhancer-binding protein)], a homeodomain gene required for basal forebrain morphogenesis, remains expressed in the hypothalamus after birth, suggesting a role in neuroendocrine function. Here,weshow an involvement of TTF1 in the control of mammalian puberty and adult reproductive function. Gene expression profiling of the nonhuman primate hypothalamus revealed...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Journal of Neuroscience
DOI: 10.1523/JNEUROSCI.4238-06.2006


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