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Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthma

Herbert, Cristan; Hettiaratchi, A; Webb, Dianne; Thomas, Paul S; Foster, Paul S; Kumar, Rakesh K

Description

Background: In a mouse model of mild chronic asthma, both inflammation and remodelling can be suppressed by dexamethasone (a glucocorticoid) and roflumilast (a selective phosphodiesterase-4 inhibitor). Objective: To better understand the underlying molecular mechanisms, we investigated the effects of treatment on airway expression of inflammation-related cytokines, as well as on epithelial expression of growth factors. Methods: BALB/c mice systemically sensitized to ovalbumin were challenged...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/32332
Source: Clinical and Experimental Allergy
DOI: 10.1111/j.1365-2222.2008.02950.x

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