Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthma
Background: In a mouse model of mild chronic asthma, both inflammation and remodelling can be suppressed by dexamethasone (a glucocorticoid) and roflumilast (a selective phosphodiesterase-4 inhibitor). Objective: To better understand the underlying molecular mechanisms, we investigated the effects of treatment on airway expression of inflammation-related cytokines, as well as on epithelial expression of growth factors. Methods: BALB/c mice systemically sensitized to ovalbumin were challenged...[Show more]
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|Source:||Clinical and Experimental Allergy|
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