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Of linkers and autochaperones: an unambiguous nomenclature to identify common and uncommon themes for autotransporter secretion

Drobnak, Igor; Braselmann, Esther; Chaney, Julie L; Leyton, Denisse; Bernstein, Harris; Lithgow, Trevor; Luirink, Joen; Nataro, James; Clark, Patricia


Autotransporter (AT) proteins provide a diverse array of important virulence functions to Gram-negative bacterial pathogens, and have also been adapted for protein surface display applications. The 'autotransporter' moniker refers to early models that depicted these proteins facilitating their own translocation across the bacterial outer membrane. Although translocation is less autonomous than originally proposed, AT protein segments upstream of the C-terminal transmembrane β-barrel have...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Molecular Microbiology
DOI: 10.1111/mmi.12838


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