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Expression of a Tumor-Related Gene Network Increases in the Mammalian Hypothalamus at the Time of Female Puberty

Roth, Christian; Mastronardi, Claudio; Lomniczi, Alejandro; Wright, Hollis; Cabrera, Ricardo; Mungenast, Alison; Heger, Sabrine; Jung, Heike; Dubay, Christopher; Ojeda, Sergio R

Description

Much has been learned in recent years about the central mechanisms controlling the initiation of mammalian puberty. It is now clear that this process requires the interactive participation of several genes. Using a combination of high throughput, molecular, and bioinformatics strategies, in combination with a system biology approach, we singled out from the hypothalamus of nonhuman primates and rats a group of related genes whose expression increases at the time of female puberty. Although...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/32275
Source: Endocrinology
DOI: 10.1210/en.2007-0634

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