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Investigation of the properties of wild type and mutant alkaline phosphatase variants: a laboratory project linking genotype and phenotype

Howitt, Susan


An understanding of the link between genotype and phenotype is essential for biology students. A 3-wk laboratory project aimed at demonstrating this link and introducing early year students to some aspects of the research process is described. Students investigate the properties of wild type and mutant variants of alkaline phosphatase using the techniques of both biochemistry and molecular biology. Changes in enzyme activity are correlated with the changes in DNA sequence that introduce...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Biochemistry and Molecular Biology Education
DOI: 10.1002/bmb.91


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