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Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling

Nolan, Christopher; Leahy, J L; Delghingaro-Augusto, Viviane; Moibi, J; Soni, K; Peyot, Marie-Line; Fortier, M; Guay, C; Lamontagne, Julien; Barbeau, Annie; Przybytkowski, Ewa; Joly, Erik; Masiello, Pellegrino; Wang, S; Mitchell, G A; Prentki, Marc

Description

Aims/hypothesis: The aim of this study was to determine the role of fatty acid signalling in islet beta cell compensation for insulin resistance in the Zucker fatty fa/fa (ZF) rat, a genetic model of severe obesity, hyperlipidaemia and insulin resistance

dc.contributor.authorNolan, Christopher
dc.contributor.authorLeahy, J L
dc.contributor.authorDelghingaro-Augusto, Viviane
dc.contributor.authorMoibi, J
dc.contributor.authorSoni, K
dc.contributor.authorPeyot, Marie-Line
dc.contributor.authorFortier, M
dc.contributor.authorGuay, C
dc.contributor.authorLamontagne, Julien
dc.contributor.authorBarbeau, Annie
dc.contributor.authorPrzybytkowski, Ewa
dc.contributor.authorJoly, Erik
dc.contributor.authorMasiello, Pellegrino
dc.contributor.authorWang, S
dc.contributor.authorMitchell, G A
dc.contributor.authorPrentki, Marc
dc.date.accessioned2015-12-08T22:21:43Z
dc.identifier.issn0012-186X
dc.identifier.urihttp://hdl.handle.net/1885/32239
dc.description.abstractAims/hypothesis: The aim of this study was to determine the role of fatty acid signalling in islet beta cell compensation for insulin resistance in the Zucker fatty fa/fa (ZF) rat, a genetic model of severe obesity, hyperlipidaemia and insulin resistance
dc.publisherSpringer
dc.sourceDiabetologia
dc.subjectKeywords: cyclic AMP; enzyme inhibitor; fatty acid; forskolin; glucagon like peptide 1; glucose; incretin; insulin; lipid; palmitic acid; tetrahydrolipstatin; triacylglycerol; triacylglycerol lipase; animal cell; animal experiment; animal model; article; cell funct Fatty acid partitioning; Fatty acid signalling; Glucagon-like peptide 1; Insulin resistance; Insulin secretion; Islet beta cell compensation; Lipolysis; Triglyceride-fatty acid cycling; Zucker fatty rat
dc.titleBeta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume49
dc.date.issued2006
local.identifier.absfor060802 - Animal Cell and Molecular Biology
local.identifier.ariespublicationu4133361xPUB90
local.type.statusPublished Version
local.contributor.affiliationNolan, Christopher, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLeahy, J L, University of Vermont
local.contributor.affiliationDelghingaro-Augusto, Viviane, Universite de Montreal
local.contributor.affiliationMoibi, J, University of Vermont
local.contributor.affiliationSoni, K, Sainte-Justine Hospital
local.contributor.affiliationPeyot, Marie-Line, University of Montreal
local.contributor.affiliationFortier, M, Sainte-Justine Hospital
local.contributor.affiliationGuay, C, University of Montreal
local.contributor.affiliationLamontagne, Julien, Universite de Montreal
local.contributor.affiliationBarbeau, Annie, University of Montreal
local.contributor.affiliationPrzybytkowski, Ewa, Universite de Montreal
local.contributor.affiliationJoly, Erik, University of Montreal
local.contributor.affiliationMasiello, Pellegrino, Universite de Montreal
local.contributor.affiliationWang, S, Sainte-Justine Hospital
local.contributor.affiliationMitchell, G A, Sainte-Justine Hospital
local.contributor.affiliationPrentki, Marc, University of Montreal
local.description.embargo2037-12-31
local.bibliographicCitation.issue9
local.bibliographicCitation.startpage2120
local.bibliographicCitation.lastpage2130
local.identifier.doi10.1007/s00125-006-0305-5
dc.date.updated2015-12-08T08:37:39Z
local.identifier.scopusID2-s2.0-33745817133
CollectionsANU Research Publications

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