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AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae

Plumptre, Charles D.; Eijkelkamp, Bart A.; Morey, Jacqueline R; Behr, Felix; Counago, Rafael M; Ogunniyi, Abiodun D.; Kobe, Bostjan; O'Mara, Megan; Paton, James C.; McDevitt, Christopher A


Streptococcus pneumoniae is a globally significant human pathogen responsible for nearly 1 million deaths annually. Central to the ability of S.pneumoniae to colonize and mediate disease in humans is the acquisition of zinc from the host environment. Zinc uptake in S.pneumoniae occurs via the ATP-binding cassette transporter AdcCB, and, unusually, two zinc-binding proteins, AdcA and AdcAII. Studies have suggested that these two proteins are functionally redundant, although AdcA has remained...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Molecular Microbiology
DOI: 10.1111/mmi.12504


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