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The roles of TNF in brain dysfunction and disease

Clark, Ian A; Alleva, Lisa; Vissel, Bryce

Description

Certain cytokines, the prototype being the highly pleiotropic TNF, have many homeostatic physiological roles, are involved in innate immunity, and cause inflammation when in excess. These cytokines have long been accepted to have central roles in the pathogenesis of systemic or local non-cerebral disease states, whether acute or chronic, and whether or not caused by infectious agents. Over the last decade they have also been appreciated to be broadly important in brain physiology. As in other...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/32199
Source: Pharmacology and Therapeutics
DOI: 10.1016/j.pharmthera.2010.08.007

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