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Local expression of IDO, either alone or in combination with CD40Ig, IL10 or CTLA4Ig,inhibits indirect xenorejection responses

Mulley, William R; Li, Yu Qin; Wee, Janet L; Dodge, Natalie; Christiansen, Dale; Simeonovic, Charmaine; Ierino, Francesco; Sandrin, Mauro


Background: To overcome cell-mediated xenorejection by transgenic expression of immunomodulatory molecules by a graft, it is likely that expression of multiple molecules will be required. Previous studies support the use of the immunomodulatory agents indoleamine 2,3-dioxygenase (IDO), CD40Ig, interleukin 10 (IL10), and CTLA4Ig for suppression of rejection responses. We examined the effects of local expression of these molecules by a porcine cell line (PIEC) on indirect murine xenorejection...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Xenotransplantation
DOI: 10.1111/j.1399-3089.2008.00472.x


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