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The Nitric Oxide Theory of Aging Revisited

McCann, Samuel M; Mastronardi, Claudio; De Laurentiis, A; Rettori, V


Bacterial and viral products, such as bacterial lipopolysaccharide (LPS), cause inducible (i) NO synthase (NOS) synthesis, which in turn produces massive amounts of nitric oxide (NO). NO, by inactivating enzymes and leading to cell death, is toxic not only to invading viruses and bacteria, but also to host cells. Injection of LPS induces interleukin (IL)-1β, IL-1α, and iNOS synthesis in the anterior pituitary and pineal glands, meninges, and choroid plexus, regions outside the blood-brain...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Annals of the New York Academy of Sciences
DOI: 10.1196/annals.1356.064


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