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Imperfect coordination chemistry facilitates metal ion release in the psa permease

Counago, Rafael M; Ween, Miranda P.; Begg, Stephanie; Bajaj, Megha; Zuegg, Johannes; O'Mara, Megan; Cooper, Matthew A.; McEwan, Alastair G.; Paton, James C.; Kobe, Bostjan; McDevitt, Christopher A


The relative stability of divalent first-row transition metal ion complexes, as defined by the Irving-Williams series, poses a fundamental chemical challenge for selectivity in bacterial metal ion acquisition. Here we show that although the substrate-binding protein of Streptococcus pneumoniae, PsaA, is finely attuned to bind its physiological substrate manganese, it can also bind a broad range of other divalent transition metal cations. By combining high-resolution structural data,...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Nature Chemical Biology
DOI: 10.1038/nCHeMBIO.1382


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