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Type 2 diabetes across generations: from pathophysiology to prevention and management

Nolan, Christopher; Damm, Peter; Prentki, Marc

Description

Type 2 diabetes is now a pandemic and shows no signs of abatement. In this Seminar we review the pathophysiology of this disorder, with particular attention to epidemiology, genetics, epigenetics, and molecular cell biology. Evidence is emerging that a substantial part of diabetes susceptibility is acquired early in life, probably owing to fetal or neonatal programming via epigenetic phenomena. Maternal and early childhood health might, therefore, be crucial to the development of effective...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/32072
Source: Lancet, The (UK edition)
DOI: 10.1016/S0140-6736(11)60614-4

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