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Nerve Growth Factor-Dependent Activation of trkA Receptors in the Human Ovary Results in Synthesis of Follicle-Stimulating Hormone Receptors and Estrogen Secretion

Salas, C; Julio-Pieper, M; Valladares, M; Pommer, R; Vega, M; Mastronardi, Claudio; Kerr, B; Ojeda, Sergio R; Lara, H E; Romero, C


Context: Previous studies showed that nerve growth factor (NGF) induces the expression of functional FSH receptors (FSHR) in preantral follicles of the developing rat ovary. Objective: The objective of this study was to determine whether NGF can affect granulosa cell (GC) function in human periovulatory follicles using intact human ovaries and isolated human GCs. Patients and Interventions: Human GCs were obtained from in vitro fertilization patients and normal ovaries from women with elective...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Journal of Clinical Endocrinology and Metabolism
DOI: 10.1210/jc.2005-1925


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