Gender specific effects on the actin-remodelling protein Flightless I and TGF-beta1 contribute to impaired wound healing in aged skin
Adams, Damian H; Strudwick, Xanthe L; Kopecki, Zlatko; Hooper Jones, Jane; Matthaei, Klaus; Campbell, Hugh; Powell, Barry C; Cowin, Allison
Description
Impaired wound healing in the elderly presents a major clinical challenge. Understanding the cellular mechanisms behind age-related impaired healing is vital for developing new wound therapies. Here we show that the actin-remodelling protein, Flightless I (FliI) is a contributing factor to the poor healing observed in elderly skin and that gender plays a major role in this process. Using young and aged, wild-type and FliI overexpressing mice we found that aging significantly elevated FliI...[Show more]
Collections | ANU Research Publications |
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Date published: | 2008 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/31901 |
Source: | The International Journal of Biochemistry and Cell Biology |
DOI: | 10.1016/j.biocel.2007.11.024 |
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01_Adams_Gender_specific_effects_on_the_2008.pdf | 1.6 MB | Adobe PDF | Request a copy |
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