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Gender specific effects on the actin-remodelling protein Flightless I and TGF-beta1 contribute to impaired wound healing in aged skin

Adams, Damian H; Strudwick, Xanthe L; Kopecki, Zlatko; Hooper Jones, Jane; Matthaei, Klaus; Campbell, Hugh; Powell, Barry C; Cowin, Allison

Description

Impaired wound healing in the elderly presents a major clinical challenge. Understanding the cellular mechanisms behind age-related impaired healing is vital for developing new wound therapies. Here we show that the actin-remodelling protein, Flightless I (FliI) is a contributing factor to the poor healing observed in elderly skin and that gender plays a major role in this process. Using young and aged, wild-type and FliI overexpressing mice we found that aging significantly elevated FliI...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/31901
Source: The International Journal of Biochemistry and Cell Biology
DOI: 10.1016/j.biocel.2007.11.024

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