Gender specific effects on the actin-remodelling protein Flightless I and TGF-beta1 contribute to impaired wound healing in aged skin
Impaired wound healing in the elderly presents a major clinical challenge. Understanding the cellular mechanisms behind age-related impaired healing is vital for developing new wound therapies. Here we show that the actin-remodelling protein, Flightless I (FliI) is a contributing factor to the poor healing observed in elderly skin and that gender plays a major role in this process. Using young and aged, wild-type and FliI overexpressing mice we found that aging significantly elevated FliI...[Show more]
|Collections||ANU Research Publications|
|Source:||The International Journal of Biochemistry and Cell Biology|
|01_Adams_Gender_specific_effects_on_the_2008.pdf||1.6 MB||Adobe PDF||Request a copy|
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