Skip navigation
Skip navigation
The system will be down for maintenance between 8:00 and 8:15am on Thursday 13, December 2018

Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients

Da Paz Filho, Gilberto; Esposito, Karin; Hurwitz, Bonnie; Sharma, Anil; Dong, C.; Andreev, V P; Delibasi, Tuncay; Erol, Halil Kutlu; Ayala, A; Wong, Ma-Li; Licinio, Julio


Leptin replacement rescues the phenotype of morbid obesity and hypogonadism in leptin-deficient adults. However, leptin's effects on insulin resistance are not well understood. Our objective was to evaluate the effects of leptin on insulin resistance. Three leptin-deficient adults (male, 32 yr old, BMI 23.5 kg/m2; female, 42 yr old, BMI 25.1 kg/m2; female, 46 yr old, BMI 31.7 kg/m2) with a missense mutation of the leptin gene were evaluated during treatment with recombinant methionyl human...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: American Journal of Physiology - Endocrinology and Metabolism
DOI: 10.1152/ajpendo.90450.2008


File Description SizeFormat Image
01_Da Paz Filho_Changes_in_insulin_sensitivity_2008.pdf335.02 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  27 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator