Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients
Leptin replacement rescues the phenotype of morbid obesity and hypogonadism in leptin-deficient adults. However, leptin's effects on insulin resistance are not well understood. Our objective was to evaluate the effects of leptin on insulin resistance. Three leptin-deficient adults (male, 32 yr old, BMI 23.5 kg/m2; female, 42 yr old, BMI 25.1 kg/m2; female, 46 yr old, BMI 31.7 kg/m2) with a missense mutation of the leptin gene were evaluated during treatment with recombinant methionyl human...[Show more]
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|Source:||American Journal of Physiology - Endocrinology and Metabolism|
|01_Da Paz Filho_Changes_in_insulin_sensitivity_2008.pdf||335.02 kB||Adobe PDF||Request a copy|
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