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Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients

Da Paz Filho, Gilberto; Esposito, Karin; Hurwitz, Bonnie; Sharma, Anil; Dong, C.; Andreev, V P; Delibasi, Tuncay; Erol, Halil Kutlu; Ayala, A; Wong, Ma-Li; Licinio, Julio

Description

Leptin replacement rescues the phenotype of morbid obesity and hypogonadism in leptin-deficient adults. However, leptin's effects on insulin resistance are not well understood. Our objective was to evaluate the effects of leptin on insulin resistance. Three leptin-deficient adults (male, 32 yr old, BMI 23.5 kg/m2; female, 42 yr old, BMI 25.1 kg/m2; female, 46 yr old, BMI 31.7 kg/m2) with a missense mutation of the leptin gene were evaluated during treatment with recombinant methionyl human...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/31835
Source: American Journal of Physiology - Endocrinology and Metabolism
DOI: 10.1152/ajpendo.90450.2008

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