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The Neuroendocrine Regulation of Puberty: Is the Time Ripe for a Systems Biology Approach?

Ojeda, Sergio R; Lomniczi, Alejandro; Mastronardi, Claudio; Heger, Sabine; Roth, Christian; Parent, Anne-Simone; Matagne, Valerie; Mungenast, Alison E


The initiation of mammalian puberty requires an increase in pulsatile release of GnRH from the hypothalamus. This increase is brought about by coordinated changes in transsynaptic and glial-neuronal communication. As the neuronal and glial excitatory inputs to the GnRH neuronal network increase, the transsynaptic inhibitory tone decreases, leading to the pubertal activation of GnRH secretion. The excitatory neuronal systems most prevalently involved in this process use glutamate and the peptide...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Endocrinology
DOI: 10.1210/en.2005-1136


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