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Eosinophils from Lineage-Ablated Delta dblGATA Bone Marrow Progenitors: The dblGATA Ehancer in the Promoter of GATA-1 Is Not Essential for Differentiation Ex Vivo

Dyer, Kimberley D; Czapiga, Meggan; Foster, Barbara; Foster, Paul S; Kang, Elizabeth M; Lappas, Courtney M.; Moser, Jennifer M; Naumann, Nora; Percopo, Caroline M.; Siegel, Steven J; Swartz, Jonathan M; Ting-De Ravin, SukSee; Rosenberg, Helene F

Description

A critical role for eosinophils in remodeling of allergic airways was observed in vivo upon disruption of the dblGATA enhancer that regulates expression of GATA-1, which resulted in an eosinophil-deficient phenotype in the ΔdblGATA mouse. We demonstrate

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/31666
Source: Journal of Immunology

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