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Two levels of protection for the B cell genome during somatic hypermutation

Liu, Man; Duke, Jamie; Richter, Daniel; Garcia De Vinuesa, Maria Carola; Goodnow, Christopher; Kleinstein, Steven; Schatz, David


Somatic hypermutation introduces point mutations into immunoglobulin genes in germinal centre B cells during an immune response. The reaction is initiated by cytosine deamination by the activation-induced deaminase (AID) and completed by error-prone processing of the resulting uracils by mismatch and base excision repair factors. Somatic hypermutation represents a threat to genome integrity and it is not known how the B cell genome is protected from the mutagenic effects of somatic...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Nature
DOI: 10.1038/nature06547


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