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The nucleosome surface regulates chromatin compaction and couples it with transcriptional repression

Zhou, Jiansheng; Fan, Jun; Rangasamy, Danny; Tremethick, David


Although it is believed that the interconversion between permissive and refractory chromatin structures is important in regulating gene transcription, this process is poorly understood. Central to addressing this issue is to elucidate how a nucleosomal array folds into higher-order chromatin structures. Such findings can then provide new insights into how the folding process is regulated to yield different functional states. Using well-defined in vitro chromatin-assembly and transcription...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Nature Structural and Molecular Biology
DOI: 10.1038/nsmb1323


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