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White matter hyperintensities and within-person variability in community-dwelling adults aged 60-64 years

Bunce, David; Christensen, Helen; Dear, Keith; Wen, Wei; Sachdev, Perminder Singh; Anstey, Kaarin


Estimates of white matter hyperintensities (WMH) derived from T2-weighted MRI were investigated in relation to cognitive performance in 469 healthy community-dwelling adults aged 60-64 years. Frontal lobe WMH but not WMH from other brain regions (temporal, parietal, and occipital lobes, anterior and posterior horn, periventricular body) were associated with elevated within-person reaction time (RT) variability (trial to trial fluctuations in RT performance) but not performance on several other...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Neuropsychologia
DOI: 10.1016/j.neuropsychologia.2007.02.006


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