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Dysbiosis of the Duodenal Mucosal Microbiota Is Associated With Increased Small Intestinal Permeability in Chronic Liver Disease

Raj, Ashok S.; Shanahan, Erin R.; Tran, Cuong; Bhat, Purnima; Fletcher, L M; Vesey, David A.; Morrison, M; Holtmann, G; Macdonald, Graeme


OBJECTIVES: Chronic liver disease (CLD) is associated with both alterations of the stool microbiota and increased small intestinal permeability. However, little is known about the role of the small intestinal mucosaassociated microbiota (MAM) in CLD. The aim of this study was to evaluate the relationship between the duodenal MAM and both small intestinal permeability and liver disease severity in CLD. METHODS: Subjects with CLD and a disease-free control group undergoing routine endoscopy...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Clinical and Translational Gastroenterology
DOI: 10.14309/ctg.0000000000000068
Access Rights: Open Access


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