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Critical link between TRAIL and CCL20 for the activation of T(H)2 cells and the expression of allergic airway disease

Weckmann, Markus; Collison, Adam; Simpson, Jodie L; Kopp, Matthias; Wark, Peter A B; Smyth, Mark J; Yagita, Hideo; Matthaei, Klaus; Hansbro, Nicole; Whitehead, Bruce; Gibson, Peter G; Foster, Paul S; Mattes, Joerg


The role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in immune responses mediated by T-helper 2 (TH2) lymphocytes is unknown. Here we characterize the development of allergic airway disease in TRAIL-deficient (Tnfsf10-/-) mice and in mice exposed to short interfering RNA targeting TRAIL. We show that TRAIL is abundantly expressed in the airway epithelium of allergic mice and that inhibition of signaling impairs production of the chemokine CCL20 and homing of myeloid...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Nature Medicine
DOI: 10.1038/nm1660


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