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Bayesian Joint Estimation of CN and LOH Aberrations

Rancoita, P.M.V; Hutter, Marcus; Bertoni , Francesco; Kwee, Ivo

Description

SNP-microarrays are able to measure simultaneously both copy number and genotype at several single nucleotide polymorphism positions. Combining the two data, it is possible to better identify genomic aberrations. For this purpose, we propose a Bayesian piecewise constant regression which infers the type of aberration occurred, taking into account all the possible influence in the microarray detection of the genotype, resulting from an altered copy number level. Namely, we model the...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Conference paper
URI: http://hdl.handle.net/1885/31372
Source: Proceedings of the 3rd International Workshop on Practical Applications of Computational Biology & Bioinformatics (IWPACBB'09)
DOI: 10.1007/978-3-642-02481-8_168

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