Obesity Up-Regulates Intermediate Conductance Calcium-Activated Potassium Channels and Myoendothelial Gap Junctions to Maintain Endothelial Vasodilator Function
The mechanisms involved in altered endothelial function in obesity-related cardiovascular disease are poorly understood. This study investigates the effect of chronic obesity on endothelium-dependent vasodilation and the relative contribution of nitric oxide (NO), calcium-activated potassium channels (KCa), and myoendothelial gap junctions (MEGJs) in the rat saphenous artery. Obesity was induced by feeding rats a cafeteria-style diet (∼30 kJ as fat) for 16 to 20 weeks, with this model...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Pharmacology and Experimental Therapeutics|
|01_Chadha_Obesity_Up-Regulates_2010.pdf||2.43 MB||Adobe PDF||Request a copy|
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