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Obesity Up-Regulates Intermediate Conductance Calcium-Activated Potassium Channels and Myoendothelial Gap Junctions to Maintain Endothelial Vasodilator Function

Chadha, Preet S; Haddock, Rebecca; Howitt, Lauren; Morris, MJ; Murphy , Tim V; Grayson , T Hilton; Sandow, Shaun, L


The mechanisms involved in altered endothelial function in obesity-related cardiovascular disease are poorly understood. This study investigates the effect of chronic obesity on endothelium-dependent vasodilation and the relative contribution of nitric oxide (NO), calcium-activated potassium channels (KCa), and myoendothelial gap junctions (MEGJs) in the rat saphenous artery. Obesity was induced by feeding rats a cafeteria-style diet (∼30 kJ as fat) for 16 to 20 weeks, with this model...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Journal of Pharmacology and Experimental Therapeutics
DOI: 10.1124/jpet.110.167593


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