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Smoking as a Risk Factor for Dementia and Cognitive Decline : A Meta- Analysis of Prospective Studies

Von Sanden, Chwee Chwee; Salim, Agus; O'Kearney, Richard; Anstey, Kaarin

Description

The authors assessed the association of smoking with dementia and cognitive decline in a meta-analysis of 19 prospective studies with at least 12 months of follow-up. Studies included a total of 26,374 participants followed for dementia for 2-30 years and 17,023 participants followed up for 2-7 years to assess cognitive decline. Mean study age was 74 years. Current smokers at baseline, relative to never smokers, had risks of 1.79 (95% confidence interval (CI): 1.43, 2.23) for incident...[Show more]

dc.contributor.authorVon Sanden, Chwee Chwee
dc.contributor.authorSalim, Agus
dc.contributor.authorO'Kearney, Richard
dc.contributor.authorAnstey, Kaarin
dc.date.accessioned2015-12-08T22:18:11Z
dc.identifier.issn0002-9262
dc.identifier.urihttp://hdl.handle.net/1885/31234
dc.description.abstractThe authors assessed the association of smoking with dementia and cognitive decline in a meta-analysis of 19 prospective studies with at least 12 months of follow-up. Studies included a total of 26,374 participants followed for dementia for 2-30 years and 17,023 participants followed up for 2-7 years to assess cognitive decline. Mean study age was 74 years. Current smokers at baseline, relative to never smokers, had risks of 1.79 (95% confidence interval (CI): 1.43, 2.23) for incident Alzheimer's disease, 1.78 (95% CI: 1.28, 2.47) for incident vascular dementia, and 1.27 (95% CI: 1.02, 1.60) for any dementia. Compared with those who never smoked, current smokers at baseline also showed greater yearly declines in Mini-Mental State Examination scores over the follow-up period (effect size (β) = -0.13, 95% CI: -0.18, -0.08). Compared with former smokers, current smokers at baseline showed an increased risk of Alzheimer's disease (relative risk = 1.70, 95% CI: 1.25, 2.31) and an increased decline in cognitive abilities (effect size (β) = -0.07, 95% CI: -0.11, -0.03), but the groups were not different regarding risk of vascular dementia or any dementia. The authors concluded that elderly smokers have increased risks of dementia and cognitive decline.
dc.publisherOxford University Press
dc.sourceAmerican Journal of Epidemiology
dc.subjectKeywords: age structure; cognition; comparative study; medical geography; meta-analysis; nervous system disorder; risk factor; smoking; Alzheimer disease; article; cognitive defect; dementia; follow up; human; mini mental state examination; multiinfarct dementia; p Alzheimer disease; Cognition; Dementia, vascular; Meta-analysis; Smoking
dc.titleSmoking as a Risk Factor for Dementia and Cognitive Decline : A Meta- Analysis of Prospective Studies
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume166
dc.date.issued2007
local.identifier.absfor111714 - Mental Health
local.identifier.ariespublicationU4146231xPUB81
local.type.statusPublished Version
local.contributor.affiliationAnstey, Kaarin, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationVon Sanden, Chwee Chwee, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSalim, Agus, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationO'Kearney, Richard, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue4
local.bibliographicCitation.startpage367
local.bibliographicCitation.lastpage378
local.identifier.doi10.1093/aje/kwm116
local.identifier.absseo920410 - Mental Health
dc.date.updated2015-12-08T08:13:57Z
local.identifier.scopusID2-s2.0-34547679439
CollectionsANU Research Publications

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