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The innate immune response to adjuvants dictates the adaptive immune response to autoantigens

Staykova, Maria; Linares, David; Fordham, Susan; Paridaen, Judith T; Willenborg, David


To elucidate the role of innate immunity in susceptibility to the animal model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE), we induced EAE by immunization with spinal cord homogenate (SCH) plus complete Freund adjuvant or carbonyl iron in 3 inbred rat strains. Lewis are considered "susceptible," PVG/c-Rt7a (PVG) as "semisusceptible," and Brown Norway (BN) as "resistant" to EAE. Immunization with SCH-carbonyl iron resulted in clinical disease in all 3 strains, but the...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Journal of Neuropathology and Experimental Neurology
DOI: 10.1097/NEN.0b013e31817713cc


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