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Eosinophilic inflammation: mechanisms regulating IL-5 transcription in human T lymphocytes

Wang, Jun; Young, Ian


Background: Interleukin (IL)-5 is a key regulator of eosinophilia in allergic inflammation and parasite infections but the mechanisms regulating IL-5 expression in activated human T lymphocytes are poorly understood. From studies on mouse cells, the activation protein (AP)-1 and GATA-3 sites in the proximal promoter region appear to be important in IL-5 regulation but the significance of an adjacent Ets/nuclear factor of activated T cell (NFAT) site has been less clear. Methods: Interleukin-5...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Allergy
DOI: 10.1111/j.1398-9995.2007.01510.x


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