Macuamule, Cristiano; Tjhin, Erick; Jana, Collins E.; Barnard, Leanne; Koekemoer, Lizbe; de Villiers, Marianne; Saliba, Kevin; Strauss, Erick
Pantothenamides inhibit blood-stage Plasmodium falciparum with potencies (50% inhibitory concentration [IC50], 20 nM)
similar to that of chloroquine. They target processes dependent on pantothenate, a precursor of the essential metabolic cofactor
coenzyme A. However, their antiplasmodial activity is reduced due to degradation by serum pantetheinase. Minor modification
of the pantothenamide structure led to the identification of -methyl-N-phenethyl-pantothenamide, a pantothenamide...[Show more]
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