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Airway eosinophils: allergic inflammation recruited professional antigen-presenting cells

Wang, Hai-Bin; Ghiran, Ionita; Matthaei, Klaus; Weller, Peter F


The capacity of airway eosinophils, potentially pertinent to allergic diseases of the upper and lower airways, to function as professional APCs, those specifically able to elicit responses from unprimed, Ag-naive CD4+ T cells has been uncertain. We investigated whether airway eosinophils are capable of initiating naive T cell responses in vivo. Eosinophils, isolated free of other APCs from the spleens of IL-5 transgenic mice, following culture with GM-CSF expressed MHC class II and the...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Journal of Immunology


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