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PfNT2, a Permease of the Equilibrative Nuceloside Transporter Family in the Endoplasmic Reticulum of Plasmodium falciparum

Downie, Megan; El Bissati, Kamal; Bobenchik, April M.; Lochlainn, Laura Nic; Amerik, Alexander; Zufferey, Rachel; Kirk, Kiaran; Ben Mamoun, Choukri


The survival and proliferation of the obligate intracellular malaria parasite Plasmodium falciparum require salvage of essential purines from the host. Genetic studies have previously shown that the parasite plasma membrane purine permease, PfNT1, plays an essential function in the transport of all naturally occurring purine nucleosides and nucleobases across the parasite plasma membrane. Here, we describe an intracellular permease, PfNT2. PfNT2 is, like PfNT1, a member of the equilibrative...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M110.118489


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