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Molecular composition of the peri-islet basement membrane in NOD mice: a barrier against destructive insulitis

Irving-Rodgers, H.F.; Ziolkowski, Andrew; Parish, Christopher; Sado, Y.; Ninomiya, Y.; Simeonovic, Charmaine; Rodgers, Ray


Aims/hypothesis: This study examined whether the capsule which encases islets of Langerhans in the NOD mouse pancreas represents a specialised extracellular matrix (ECM) or basement membrane that protects islets from autoimmune attack. Methods: Immunofluorescence microscopy using a panel of antibodies to collagens type IV, laminins, nidogens and perlecan was performed to localise matrix components in NOD mouse pancreas before diabetes onset, at onset of diabetes and after clinical diabetes was...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Diabetologia
DOI: 10.1007/s00125-008-1085-x


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