Nolan, Christopher; Delghingaro-Augusto, Viviane
In this issue, Cnop et al. (1) report on using RNA-sequencing methodology and the response of the whole transcriptome of human islets to 48-h exposure to saturated free fatty acid (FFA) palmitate. They demonstrated that palmitate altered the expression of 1,325 genes and shifted alternate splicing of 3,525 transcripts. This follows on from a similar study by
the same group on the effects on human islets of 48-h
exposure to the proinflammatory cytokines interleukin-1b
and interferon-g in...[Show more]
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