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RNA sequencing of all transcripts and how islet β-cells fail

Nolan, Christopher; Delghingaro-Augusto, Viviane


In this issue, Cnop et al. (1) report on using RNA-sequencing methodology and the response of the whole transcriptome of human islets to 48-h exposure to saturated free fatty acid (FFA) palmitate. They demonstrated that palmitate altered the expression of 1,325 genes and shifted alternate splicing of 3,525 transcripts. This follows on from a similar study by the same group on the effects on human islets of 48-h exposure to the proinflammatory cytokines interleukin-1b and interferon-g in...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Diabetes
DOI: 10.2337/db14-0290


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