RNA sequencing of all transcripts and how islet β-cells fail
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Nolan, Christopher; Delghingaro-Augusto, Viviane
Description
In this issue, Cnop et al. (1) report on using RNA-sequencing methodology and the response of the whole transcriptome of human islets to 48-h exposure to saturated free fatty acid (FFA) palmitate. They demonstrated that palmitate altered the expression of 1,325 genes and shifted alternate splicing of 3,525 transcripts. This follows on from a similar study by the same group on the effects on human islets of 48-h exposure to the proinflammatory cytokines interleukin-1b and interferon-g in...[Show more]
Collections | ANU Research Publications |
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Date published: | 2014 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/30922 |
Source: | Diabetes |
DOI: | 10.2337/db14-0290 |
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01_Nolan_RNA_sequencing_of_all_2014.pdf | 706.64 kB | Adobe PDF | Request a copy |
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