Skip navigation
Skip navigation

RNA sequencing of all transcripts and how islet β-cells fail

Nolan, Christopher; Delghingaro-Augusto, Viviane

Description

In this issue, Cnop et al. (1) report on using RNA-sequencing methodology and the response of the whole transcriptome of human islets to 48-h exposure to saturated free fatty acid (FFA) palmitate. They demonstrated that palmitate altered the expression of 1,325 genes and shifted alternate splicing of 3,525 transcripts. This follows on from a similar study by the same group on the effects on human islets of 48-h exposure to the proinflammatory cytokines interleukin-1b and interferon-g in...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/30922
Source: Diabetes
DOI: 10.2337/db14-0290

Download

File Description SizeFormat Image
01_Nolan_RNA_sequencing_of_all_2014.pdf706.64 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  23 August 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator