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Alanine metabolism, transport, and cycling in the brain

Broer, Stefan; Broer, Angelika; Hansen, Jonas T.; Bubb, William A; Balcar, Vladimir J; Nasrallah, Fatima A.; Garner, Brett; Rae, Caroline

Description

Brain glutamate/glutamine cycling is incomplete without return of ammonia to glial cells. Previous studies suggest that alanine is an important carrier for ammonia transfer. In this study, we investigated alanine transport and metabolism in Guinea pig brain cortical tissue slices and prisms, in primary cultures of neurons and astrocytes, and in synaptosomes. Alanine uptake into astrocytes was largely mediated by system L isoform LAT2, whereas alanine uptake into neurons was mediated by...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/30913
Source: Journal of Neurochemistry
DOI: 10.1111/j.1471-4159.2007.04654.x

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