Skip navigation
Skip navigation

Histone-mediated transduction as an efficient means for gene delivery

Wagstaff, Kylie; Glover, Dominic J; Tremethick, David; Jans, David A


Gene delivery into the nucleus of eukaryotic cells is inefficient, largely because of the significant barriers within the target cell of the plasma membrane and nuclear envelope. Recently, a group of basic proteins, including the HIV-1 Tat protein and the four core histones, have been shown to enter cells through a novel energy- and receptor-independent manner. Here, we show that engineered histone H2B proteins are able to mediate the efficient delivery of either green fluorescent protein or...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Molecular therapy : the journal of the American Society of Gene Therapy
DOI: 10.1038/


File Description SizeFormat Image
01_Wagstaff_Histone-mediated_transduction_2007.pdf1.57 MBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator