Histone-mediated transduction as an efficient means for gene delivery
Gene delivery into the nucleus of eukaryotic cells is inefficient, largely because of the significant barriers within the target cell of the plasma membrane and nuclear envelope. Recently, a group of basic proteins, including the HIV-1 Tat protein and the four core histones, have been shown to enter cells through a novel energy- and receptor-independent manner. Here, we show that engineered histone H2B proteins are able to mediate the efficient delivery of either green fluorescent protein or...[Show more]
|Collections||ANU Research Publications|
|Source:||Molecular therapy : the journal of the American Society of Gene Therapy|
|01_Wagstaff_Histone-mediated_transduction_2007.pdf||1.57 MB||Adobe PDF||Request a copy|
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