Histone-mediated transduction as an efficient means for gene delivery
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Wagstaff, Kylie; Glover, Dominic J; Tremethick, David; Jans, David A
Description
Gene delivery into the nucleus of eukaryotic cells is inefficient, largely because of the significant barriers within the target cell of the plasma membrane and nuclear envelope. Recently, a group of basic proteins, including the HIV-1 Tat protein and the four core histones, have been shown to enter cells through a novel energy- and receptor-independent manner. Here, we show that engineered histone H2B proteins are able to mediate the efficient delivery of either green fluorescent protein or...[Show more]
Collections | ANU Research Publications |
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Date published: | 2007 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/30883 |
Source: | Molecular therapy : the journal of the American Society of Gene Therapy |
DOI: | 10.1038/sj.mt.6300093 |
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01_Wagstaff_Histone-mediated_transduction_2007.pdf | 1.57 MB | Adobe PDF | Request a copy |
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