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Strain-dependent resistance to allergen-induced lung pathophysiology in mice correlates with rate of apoptosis of lung-derived eosinophils

Tumes, Damon J; Cormie, James; Calvert, Michael G; Stewart, Kalev; Nassenstein, Christina; Braun, Armin; Foster, Paul S; Dent, Lindsay


Although exposed to similar allergic and environmental stimuli, not all humans develop asthma. Similarly, mouse strains vary in the degree of pathophysiology seen following induction of experimental asthma. Three mouse strains (CBA/Ca, BALB/c, and C57BL/6) were used to determine if the extent and duration of inflammation influenced the degree of lung tissue damage in an OVA-induced allergic asthma model. Airways obstruction, leukocyte infiltration, edema, eosinophil accumulation, and...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Journal of Leukocyte Biology
DOI: 10.1189/jlb.0106046


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