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Evolution of Genomic Imprinting: Insights from Marsupials and Monotremes

Renfree, Marilyn B; Hore, Tim; Shaw, Geoffrey; Graves, Jennifer; Pask, Andrew J

Description

Parent-of-origin gene expression (genomic imprinting) is widespread among eutherian mammals and also occurs in marsupials. Most imprinted genes are expressed in the placenta, but the brain is also a favored site. Although imprinting evolved in therian mammals before the marsupial-eutherian split, the mechanisms have continued to evolve in each lineage to produce differences between the two groups in terms of the number and regulation of imprinted genes. As yet there is no evidence for genomic...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/30585
Source: Annual Review of Genomics and Human Genetics
DOI: 10.1146/annurev-genom-082908-150026

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