Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3
Hyper-immunoglobulin E syndrome (HIES) is a primary immune def ciency characterized by abnormal and devastating susceptibility to a narrow spectrum of infections, most commonly Staphylococcus aureus and Candida albicans. Recent investigations have identified mutations in STAT3 in the majority of HIES patients studied. Despite the identification of the genetic cause of HIES, the mechanisms underlying the pathological features of this disease remain to be elucidated. Here, we demonstrate a...[Show more]
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|Source:||Journal of Experimental Medicine|
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