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Sex-specific splicing of Z- and W-borne nr5a1 alleles suggests sex determination is controlled by chromosome conformation

Zhang, Xiuwen; Wagner, Susan; Holleley, Clare E.; Deakin, Janine; Matsubaraa, Kazumi; Deveson, Ira; O’Meally, Denis; Patel, Hardip; Ezaz, Tariq; Li, Zhao; Wang, Chexu

Description

Pogona vitticeps has female heterogamety (ZZ/ZW), but the master sex-determining gene is unknown, as it is for all reptiles. We show that nr5a1 (Nuclear Receptor Subfamily 5 Group A Member 1), a gene that is essential in mammalian sex determination, has alleles on the Z and W chromosomes (Z-nr5a1 and W-nr5a1), which are both expressed and can recombine. Three transcript isoforms of Z-nr5a1 were detected in gonads of adult ZZ males, two of which encode a functional protein. However, ZW females...[Show more]

CollectionsANU Research Publications
Date published: 2022
Type: Journal article
URI: http://hdl.handle.net/1885/303306
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.2116475119

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