E Protein Domain III Determinants of Yellow Fever Virus 17DVaccine Strain Enhance Binding to Glycosaminoglycans,Impede Virus Spread, and Attenuate Virulence
The yellow fever virus (YFV) 17D strain is one of the most effective live vaccines for human use, but the in vivo mechanisms for virulence attenuation of the vaccine and the corresponding molecular determinants remain elusive. The vaccine differs phenotypically from wild-type YFV by the loss of viscerotropism, despite replicative fitness in cell culture, and genetically by 20 amino acid changes predominantly located in the envelope (E) protein. We show that three residues in E protein domain...[Show more]
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|Source:||Journal of Virology|
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