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Involvement of nonselective cation channels in the depolarisation initiating vasomotion

Wolfle, Stephanie; Navarro-Gonzalez, Manuel; Grayson, Hilton; Stricker, Christian; Hill, Caryl

Description

1. Coordinated oscillations in diameter occur spontaneously in cerebral vessels and depend on the opening of voltage dependent calcium channels. However, the mechanism that induces the initial depolarisation has remained elusive. We investigated the involvement of canonical transient receptor potential (TRPC) channels, which encode nonselective cation channels passing Na+ and Ca2+ currents, by measuring changes in diameter, intracellular Ca2+ and membrane potential in branches of juvenile rat...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/30145
Source: Clinical and Experimental Pharmacology and Physiology
DOI: 10.1111/j.1440-1681.2010.05350.x

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