Phipps, Simon; Lam, Chuan En; Mahalingam, Suresh (Surendran); Newhouse, Matthew; Ramirez, Ruben; Rosenberg, Helene F; Foster, Paul S; Matthaei, Klaus
Eosinophils are recruited to the lungs in response to respiratory syncytial virus (RSV) infection; however, their role in promoting antiviral host defense remains unclear. Here, we demonstrate that eosinophils express TLRs that recognize viral nucleic acids, are activated and degranulate after singlestranded RNA (ssRNA) stimulation of the TLR-7-MyD88 pathway, and provide host defense against RSV that is MyD88 dependent. In contrast to wild-type mice, virus clearance from lung tissue was more...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.