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Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus

Phipps, Simon; Lam, Chuan En; Mahalingam, Suresh (Surendran); Newhouse, Matthew; Ramirez, Ruben; Rosenberg, Helene F; Foster, Paul S; Matthaei, Klaus

Description

Eosinophils are recruited to the lungs in response to respiratory syncytial virus (RSV) infection; however, their role in promoting antiviral host defense remains unclear. Here, we demonstrate that eosinophils express TLRs that recognize viral nucleic acids, are activated and degranulate after singlestranded RNA (ssRNA) stimulation of the TLR-7-MyD88 pathway, and provide host defense against RSV that is MyD88 dependent. In contrast to wild-type mice, virus clearance from lung tissue was more...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/29988
Source: Blood
DOI: 10.1182/blood-2007-01-071340

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