Skip navigation
Skip navigation

Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus

Phipps, Simon; Lam, Chuan En; Mahalingam, Suresh (Surendran); Newhouse, Matthew; Ramirez, Ruben; Rosenberg, Helene F; Foster, Paul S; Matthaei, Klaus


Eosinophils are recruited to the lungs in response to respiratory syncytial virus (RSV) infection; however, their role in promoting antiviral host defense remains unclear. Here, we demonstrate that eosinophils express TLRs that recognize viral nucleic acids, are activated and degranulate after singlestranded RNA (ssRNA) stimulation of the TLR-7-MyD88 pathway, and provide host defense against RSV that is MyD88 dependent. In contrast to wild-type mice, virus clearance from lung tissue was more...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Blood
DOI: 10.1182/blood-2007-01-071340


File Description SizeFormat Image
01_Phipps_Eosinophils_contribute_to_2007.pdf515.1 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  17 November 2022/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator