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Dramatic Regulation of Heparanase Activity and Angiogenesis Gene Expression in Synovium From Patients With Rheumatoid Arthritis

Li, Rachel; Freeman, Craig; Yu, Di; Hindmarsh, Elizabeth; Tymms, Kathleen; Smith, Paul; Parish, Christopher


Objective. Although heparanase is recognized as a proangiogenic factor, the involvement of heparanase in rheumatoid arthritis (RA) is unclear. In this study, we assessed heparanase activity in synovial fluid (SF) and synovial tissue (ST) from patients with RA or osteoarthritis (OA), and analyzed the expression of angiogenic pathway-focused genes in ST from RA and OA patients. Methods. SF and ST were obtained from the knees of patients with either RA or OA and from asymptomatic donors with no...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Arthritis & Rheumatism
DOI: 10.1002/art.23489


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