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The contribution of toll-like receptors to the pathogenesis of asthma

Phipps, Simon; Lam, Chuan En; Foster, Paul S; Matthaei, Klaus

Description

Asthma is a major disease in the westernized world and its incidence has significantly increased over the past 40 years. Our understanding of the pathogenesis of asthma remains rudimentary, and for this reason, little has been accomplished by way of targeted intervention, either at a population level (to reduce the overall prevalence) or at an individual level (to treat the cause). Instead, the management strategy currently in use relies on broad-spectrum anti-inflammatory agents, generally...[Show more]

dc.contributor.authorPhipps, Simon
dc.contributor.authorLam, Chuan En
dc.contributor.authorFoster, Paul S
dc.contributor.authorMatthaei, Klaus
dc.date.accessioned2015-12-08T22:13:33Z
dc.identifier.issn0818-9641
dc.identifier.urihttp://hdl.handle.net/1885/29870
dc.description.abstractAsthma is a major disease in the westernized world and its incidence has significantly increased over the past 40 years. Our understanding of the pathogenesis of asthma remains rudimentary, and for this reason, little has been accomplished by way of targeted intervention, either at a population level (to reduce the overall prevalence) or at an individual level (to treat the cause). Instead, the management strategy currently in use relies on broad-spectrum anti-inflammatory agents, generally glucocorticoids and long-acting β2 agonists. The recent discovery of toll-like receptors (TLRs), with their role as the initiators of the innate immune response and inflammation, suggests that modulating these receptors may be beneficial in the treatment of allergic disorders. We review here the cellular distribution of TLR in the lung and their potential contribution to the processes that promote T helper 2 (Th2) immunity and infection-induced exacerbations of allergic lung disease.
dc.publisherBlackwell Publishing Ltd
dc.sourceImmunology and Cell Biology
dc.subjectKeywords: toll like receptor; allergic disease; asthma; cellular distribution; dendritic cell; disease exacerbation; eosinophil; human; immunomodulation; inflammation; innate immunity; mast cell; microbial contamination; nonhuman; respiratory epithelium; review; Th Asthma; Pathogenesis; Toll-like receptors
dc.titleThe contribution of toll-like receptors to the pathogenesis of asthma
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume85
dc.date.issued2007
local.identifier.absfor060111 - Signal Transduction
local.identifier.ariespublicationu4020362xPUB69
local.type.statusPublished Version
local.contributor.affiliationPhipps, Simon, University of Newcastle
local.contributor.affiliationLam, Chuan En, University of Newcastle
local.contributor.affiliationFoster, Paul S, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMatthaei, Klaus, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue6
local.bibliographicCitation.startpage463
local.bibliographicCitation.lastpage70
local.identifier.doi10.1038/sj.icb.7100104
dc.date.updated2015-12-08T07:44:14Z
local.identifier.scopusID2-s2.0-34548448134
CollectionsANU Research Publications

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