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Effect of the Ion-Protein Dispersion Interactions on the Protein-Surface and Protein-Protein Interactions

Moreira, Livia A; Bostrom, Mathias Anders; Ninham, Barry; Biscaia, Evaristo C; Tavares, Frederico W

Description

Interactions between proteins are studied by calculating the potential of mean force based on the Poisson-Boltzmann equation. We define a parameter that allows a comparison between the osmotic second virial coefficients obtained from different experimental analytical techniques and provides information about both protein-protein or protein-surface interactions. It can be related to the protein solubility and be used to determine favorable conditions for protein adsorption on a specific surface...[Show more]

dc.contributor.authorMoreira, Livia A
dc.contributor.authorBostrom, Mathias Anders
dc.contributor.authorNinham, Barry
dc.contributor.authorBiscaia, Evaristo C
dc.contributor.authorTavares, Frederico W
dc.date.accessioned2015-12-08T22:11:33Z
dc.identifier.issn0103-5053
dc.identifier.urihttp://hdl.handle.net/1885/29843
dc.description.abstractInteractions between proteins are studied by calculating the potential of mean force based on the Poisson-Boltzmann equation. We define a parameter that allows a comparison between the osmotic second virial coefficients obtained from different experimental analytical techniques and provides information about both protein-protein or protein-surface interactions. It can be related to the protein solubility and be used to determine favorable conditions for protein adsorption on a specific surface or protein aggregation. The calculations show reasonable agreement with the experimental second virial coefficient. They also reveal that it is possible to predict different Hofmeister effects observed experimentally in protein solutions. We demonstrate that the effect of including many-body ion-protein dispersion potentials originating from polarizabilities of ions and proteins may offer an explanation for the Hofmeister series. In particular, we give evidence for the inversion of Hofmeister series as function of pH for a given protein.
dc.publisherSociedade Brasileira de Quimica
dc.sourceJournal of the Brazilian Chemical Society
dc.subjectKeywords: Hofmeister series; Osmotic second virial coefficient; Protein adsorption; Van der Waals interactions
dc.titleEffect of the Ion-Protein Dispersion Interactions on the Protein-Surface and Protein-Protein Interactions
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume18
dc.date.issued2007
local.identifier.absfor030603 - Colloid and Surface Chemistry
local.identifier.ariespublicationu9210271xPUB68
local.type.statusPublished Version
local.contributor.affiliationMoreira, Livia A, Universidade Federal do Rio de Janeiro
local.contributor.affiliationBostrom, Mathias Anders, Linkoping University
local.contributor.affiliationNinham, Barry, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationBiscaia, Evaristo C, Universidade Federal do Rio de Janeiro
local.contributor.affiliationTavares, Frederico W, Universidade Federal do Rio de Janeiro
local.description.embargo2037-12-31
local.bibliographicCitation.issue1
local.bibliographicCitation.startpage223
local.bibliographicCitation.lastpage230
local.identifier.doi10.1590/S0103-50532007000100026
dc.date.updated2015-12-08T07:42:08Z
local.identifier.scopusID2-s2.0-33947241435
CollectionsANU Research Publications

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